Wei Wang,Laura McKinley,Benjamin Wong,Karl Olney,Tracey Tien
申请号：
US14843128
公开号：
US20170056164A1
申请日:
2015.09.02
申请国别(地区):
US
年份:
2017
代理人:
摘要：
A transcatheter valve prosthesis including a sealing component formed from a tissue having an altered extracellular matrix. The altered extracellular matrix includes at least one weakened connection such that the tissue is configured to swell or expand upon contact with a fluid. The altered extracellular matrix does not reduce compressibility of the tissue such that the delivery profile of the transcatheter valve prosthesis is not adversely affected. The tissue having an altered extracellular matrix transforms from a compressed state for delivery within a vasculature to an expanded state in situ when blood infiltrates or flows within the at least one weakened connection. The sealing component in the expanded state conforms to the geometry of the native valve tissue, thereby preventing paravalvular leakage at the implantation site.
