EASTERN VIRGINIA MEDICAL SCHOOL;CHILDREN'S HEALTH FOUNDATION, INC.;ERIKO LIFE SCIENCES VENTURES, LLC
发明人:
KRISHNA, NEEL K.,CUNNION, KENJI
申请号：
CA2987141
公开号：
CA2987141A1
申请日:
2016.06.24
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
The present invention provides synthetic peptide compounds and uses thereof for therapy and diagnostics of complement-mediated diseases, such as inflammatory diseases, autoimmune diseases, and microbial and bacterial infections； and non-complement-mediated diseases, such cystic fibrosis and various acute diseases. The invention is directed to modifications of a synthetic peptide of 15 amino acids from the Polar Assortant (PA) peptide, which is a scrambled peptide derived from human Astrovirus protein. In some embodiments, the invention is directed to peptide compounds that are peptide mimetics, peptide analogs and/or synthetic derivatives of PA (e.g., sarcosine derivatives) having, for example, internal peptide substitutions, and modifications, including PEGylation at the N-terminus and C-terminus. The invention further provides methods of selecting at least one synthetic peptide for treating various conditions.
