SEIDEL, RONALD D., III,塞德尔 罗纳德 Ｄ 三世,塞德爾 羅納德 Ｄ 三世,CHAPARRO, RODOLFO J.,查帕罗 鲁道夫 Ｊ,查帕羅 鲁道夫 Ｊ,ROSS, JOHN F.,罗斯 约翰 Ｆ,羅斯 約翰 Ｆ
申请号：
TW107131318
公开号：
TW201925235A
申请日:
2018.09.06
申请国别(地区):
TW
年份:
2019
代理人:
摘要：
The present disclosure provides antigen-presenting polypeptides, including single-chain antigen-presenting polypeptides and multimeric antigen-presenting polypeptides comprising one or more chemical conjugation sites for incorporation of, for example, epitope containing polypeptides. The present disclosure provides nucleic acids comprising nucleotide sequences encoding antigen-presenting polypeptides comprising one or more chemical conjugation sites, as well as cells genetically modified with the nucleic acids. The single-chain and multimeric antigen-presenting polypeptides and their epitope conjugates are useful for modulating the activity of a T-cell, and accordingly, the present disclosure provides methods of modulating activity of a T-cellin vitroandin vivoas a method of treatment.本發明提供抗原呈現多肽，包括單鏈抗原呈現多肽及多聚體抗原呈現多肽，該等抗原呈現多肽包含一或多個化學結合位點以用於併入例如含抗原決定基之多肽。本發明提供包含編碼包含一或多個化學結合位點之抗原呈現多肽之核苷酸序列的核酸以及經該等核酸基因修飾之細胞。該等單鏈及多聚體抗原呈現多肽及其抗原決定基結合物可用於調節T細胞之活性，且因此，本發明提供活體外及活體內調節T細胞活性之方法作為治療方法。
