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Benzopyran and benzoxepin PI3K inhibitor compounds and methods of use
专利权人:
F. Hoffmann-La Roche AG;Genentech, Inc.; Inc.;Genentech
发明人:
Sutherlin, Daniel P.,Folkes, Adrian,Do, Steven,Kolesnikov, Aleksandr,Siu, Michael,Pegg, Neil,Heffron, Tim,Olivero, Alan G.,Goldsmith, Richard,Bayliss, Tracy,Zhu, Bing-yan,Goldsmith, Paul,Staben, Steve
申请号:
AU2009231885
公开号:
AU2009231885B2
申请日:
2009.03.30
申请国别(地区):
AU
年份:
2014
代理人:
摘要:
Benzopyran and benzoxepin compounds of Formulas I and II, and including stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting lipid kinases including p110 alpha and other isoforms of PI3K, and for treating disorders such as cancer mediated by lipid kinases. Methods of using compounds of Formulas I and II for
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