WATSON, ALISON ANN,NASH, ROBERT JAMES,EVINSON, EMMA LOUISA
申请号：
CA2513881
公开号：
CA2513881C
申请日:
2004.01.21
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
Isolated immunomodulatory (e.g. immunostimulatory) polyhydroxlatedpyrrolizidine compounds having the formula (I), wherein R is selected from thegroup comprising hydrogen, straight or branched, unsubstituted or substituted,saturated or unsaturated acyl, alkyl (e.g. cycloalkyl), alkenyl, alkynyl andaryl groups, or a pharmaceutically acceptable salt or derivative thereof, areuseful in therapy and prophylaxis, including increasing the Th1:Th2 responseratio, haemorestoration, alleviation of immunosuppression, cytokinestimulation, treatment of proliferative disorders (e.g. cancer), vaccination,stimulation of the innate immune response and boosting of the activity ofendogenous NK cells.
