Robert James Nash;Alison Ann Watson;Emma Louisa Evinson
发明人:
Alison Ann Watson,Robert James Nash,Emma Louisa Evinson
申请号：
US10543014
公开号：
US08383665B2
申请日:
2004.01.21
申请国别(地区):
US
年份:
2013
代理人:
摘要：
Isolated immunomodulatory (e.g. immunostimulatory) polyhydroxlated pyrrolizidine compounds having the formulaare disclosed. In these compounds R is selected from hydrogen, straight or branched, unsubstituted or substituted, saturated or unsaturated acyl, alkyl (e.g. cycloalkyl), alkenyl, alkynyl and aryl groups. The compounds are useful in therapy and prophylaxis, including increasing the Th1:Th2 response ratio, hemorestoration, alleviation of immunosuppression, cytokine stimulation, treatment of proliferative disorders (e.g. cancer), vaccination, stimulation of the innate immune response and boosting of the activity of endogenous NK cells.
