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PHARMACEUTICAL PREPARATIONS OF HUMAN RPE CELLS AND USES THEREOF
专利权人:
Astellas Institute for Regenerative Medicine
发明人:
GAY, Roger,KLIMANSKAYA, Irina,LANZA, Robert
申请号:
DK12848968
公开号:
DK2780022T3
申请日:
2012.11.14
申请国别(地区):
DK
年份:
2019
代理人:
摘要:
This disclosure provides the first description of hESC-derived cells transplanted into human patients. Results are reported for one patient with each of Stargardt's Macular Dystrophy (SMD) and Dry Age-Related Macular Degeneration (AMD). Controlled hESC differentiation resulted in near-100% pure RPE populations. Immediately after surgery, hyperpigmentation was visible at the transplant site in both patients, with subsequent evidence the cells had attached and integrated into the native RPE layer. No signs of inflammation or hyperproliferation were observed. The hESC-derived RPE cells have shown no signs of rejection or tumorigenicity at the time of this report. Visual measurements suggest improvement in both patients.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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