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PHARMACEUTICAL PREPARATIONS OF HUMAN RPE CELLS AND USES THEREOF
专利权人:
发明人:
Roger Gay,Irina V. Klimanskaya,Robert P. Lanza
申请号:
US14713108
公开号:
US20150366915A1
申请日:
2015.05.15
申请国别(地区):
US
年份:
2015
代理人:
摘要:
This disclosure provides the first description of hESC-derived cells transplanted into human patients. Results are reported for one patient with each of Stargardts Macular Dystrophy (SMD) and Dry Age-Related Macular Degeneration (AMD). Controlled hESC differentiation resulted in near-100% pure RPE populations. Immediately after surgery, hyperpigmentation was visible at the transplant site in both patients, with subsequent evidence the cells had attached and integrated into the native RPE layer. No signs of inflammation or hyperproliferation were observed. The hESC-derived RPE cells have shown no signs of rejection or tumorigenicity at the time of this report. Visual measurements suggest improvement in both patients.
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