HUANG, CHI YING,黄奇英,黃奇英,HSU, WEI HSIANG,许伟祥,許偉祥,JHUANG, HONG JHIH,庄弘志,莊弘志,CHEN, YAN XI,陈彦羲,陳彥羲
申请号：
TW103138926
公开号：
TW201532610A
申请日:
2014.11.10
申请国别(地区):
TW
年份:
2015
代理人:
摘要：
The preset invention relates to a new approach for treating a metabolic disease, such as diabetes, obesity or fatty liver disease using a dimethyl sulfoxide (DMSO) extract or fraction from Graptopetalum sp. or Rhodiola sp., or an active compound isolated from the DMSO extract or fraction. Also provided in the present invention is the use of the dimethyl sulfoxide (DMSO) extract or fraction from Graptopetalum sp. or Rhodiola sp., or the active compound isolated from the DMSO extract or fraction in activating AMPK pathway and autophagy pathway, which can be used in prevention or treatment of a neurodegenerative disease or amyloid-related disease, such as Alzheimer’s disease.本發明係關於一種治療代謝性疾病，如糖尿病、肥胖或脂肪肝疾病的新穎方法，其使用來自縞辦屬(Graptopetalum sp.)或紅景天屬(Rhodiola sp.)的二甲亞碸(DMSO)萃取物或級分或分離自該DMSO萃取物或級分的活性化合物。本發明中亦提供來自縞辦屬或紅景天屬的二甲亞碸(DMSO)萃取物或級分、或分離自該DMSO萃取物或級分的活性化合物在活化AMPK途徑及自噬途徑的用途，其可被用於神經退化性疾病或澱粉樣蛋白相關疾病的預防或治療，例如阿茲海默症。
