Tibor KELER,Israel LOWY,Laura A. VITALE,Diann BLANSET,Mohan SRINIVASAN
申请号：
US12247032
公开号：
US20120114662A1
申请日:
2008.10.07
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Isolated human monoclonal antibodies which bind to Anthrax protective antigen are disclosed. The human antibodies can be produced in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are derivatives of the human antibodies (e.g., bispecific antibodies and immunoconjugates), pharmaceutical compositions comprising the human antibodies, non-human transgenic animals and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
