Keler, Tibor,Blanset, Diann,Lowy, Israel,Vitale, Laura A.,Srinivasan, Mohan
申请号：
AU2004270103
公开号：
AU2004270103B2
申请日:
2004.05.21
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
Isolated human monoclonal antibodies which bind to Anthrax protective antigen 035 disclosed. The human antibodies can be produced in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. A1so disclosed are derivatives of the human antibodies (e.g., bispecific antibodies and immunoconjugates), pharmaceutical compositions comprising the human antibodies, non-human transgenic animals and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
