The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services
发明人:
Leysath, Clinton Edward,Leppla, Stephen H.,Phillips, Damilola Daniel
申请号：
AU2013305744
公开号：
AU2013305744A1
申请日:
2013.08.22
申请国别(地区):
AU
年份:
2015
代理人:
摘要：
The present invention provides methods and systems for targeted delivery of a compound to a target cell that over-expresses two different proteinases. Specifically, two different modified protective antigen proteins, each comprising a cleavage site recognized by a distinct proteinase in place of the native proteinase cleavage site recognized by furin, are administered in combination with a compound that contains a protective antigen binding site. Upon cleavage by the two proteinases the two modified protective antigen proteins form a hetero-oligomer, allowing the compound to bind to the hetero-oligomer and subsequently to be translocated into the target cell.
