VAN LOEVEZIJN, ARNOLD,IWEMA BAKKER, WOUTER I.,STOIT, AXEL,RENSINK, AGATHA A.M.,VENHORST, JENNIFER,VAN DER NEUT, MARTINA A.W.,DE HAAN, MARTIN,KRUSE, CORNELIS G.
申请号：
DK09721279
公开号：
DK2265589T3
申请日:
2009.03.17
申请国别(地区):
DK
年份:
2016
代理人:
摘要：
This invention concerns arylsulfonyl pyrazoline carboxamidine derivatives as antagonists of 5-HT 6 receptors, to methods for the preparation of these compounds and to novel intermediates useful for their synthesis. The invention also relates to the uses of such compounds and compositions, particularly their use in administering them to patients to achieve a therapeutic effect in Parkinson's disease, Huntington's chorea, schizophrenia, anxiety, depression, manic depression, psychoses, epilepsy, obsessive compulsive disorders, mood disorders, migraine, Alzheimer's disease, age related cognitive decline, mild cognitive impairment, sleep disorders, eating disorders, anorexia, bulimia, binge eating disorders, panic attacks, akathisia, attention deficit hyperactivity disorder, attention deficit disorder, withdrawal from abuse of cocaine, ethanol, nicotine or benzodiazepines, pain, disorders associated with spinal trauma or head injury, hydrocephalus, functional bowel disorder, Irritable Bowel Syndrome, obesity and type-2 diabetes. The compounds have the general formula (1): wherein the symbols have the meanings given in the description.
