Methods for preparing stable deoxygenated PEG-hemoglobin conjugate solutions comprising an antioxidant

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专利权人:

Kim D. Vandegriff

发明人:

Kim D. Vandegriff,Ashok S. Malavalli

申请号：

US13224084

公开号：

US08609815B2

申请日:

2011.09.01

申请国别(地区):

US

年份:

2013

代理人:

摘要：

The present invention is a method for preparing stable HBOC solutions. Specifically, the method comprises the steps of deoxygenating a PEG-Hb conjugate and adding one or more antioxidants during or following the deoxygenating step to form a stabilized PEG-Hb conjugate. The Hb in the PEG-Hb conjugate is not crosslinked and the stabilized PEG-Hb conjugate has a p50 less than that of native SFH from the same animal source when measured under the same conditions. Specifically, the p50 is 6±2 mmHg or less than 10 mmHg.

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