An infusion-leakage detection device includes: a substrate a circuit with an infusion-leakage detection region formed on the substrate and aligned to an IV catheter which is inserted into a blood vessel of a patient, and the region includes at least a light-emitting element emitting a light with wavelength within the second optical window of biological organization and at least a light detector receiving the light to generate an electrical signal and a circuit and battery region formed on the substrate, including a control and calculation unit connecting to the light-emitting element, and an acceleration detector connecting to the control and calculation unit, sensing body movement of a patient and providing a body-movement signal to the control and calculation unit. A remote monitoring system including the infusion-leakage detection device and remote equipment which receive information of leakage/no-leakage and alarm signal to monitor infusion-leakage status remotely.
