Being method and the system for last sterilization and the surface decontamination of the advance filling up container, the advance filling up container, if it is not that, because it is temperature or radiation receptibility, includes receptible medical supply such as the biotechnology medical supply which is not suited for the last sterilization with the conventional method of needing the steam or gamma-ray. As for the said method and the system, especially it is suited for the advance filling up container in second packing. As for method, the last sterilization with disclosing the advance filling up container in second packing to adjustment possible beta radiation is included, spread to the advance filling up container of steam conversion hydrogen peroxide is made to decrease or including the application of expedient in order to prevent, the last sterilization with disclosing the advance filling up container to control possible steam conversion hydrogen peroxide furthermore is included.事前充填容器の最終滅菌および表面除染のための方法およびシステムであって、事前充填容器は、それがなければ、温度または放射線感応性であるため、蒸気またはガンマ線を必要とする古典的な方法による最終滅菌に適さない生物工学医薬品などの感応性医薬品を含む。該方法およびシステムは、二次包装における事前充填容器に特に適する。方法は、二次包装における事前充填容器を調整可能ベータ放射線に曝露することによる最終滅菌を含み、蒸気化過酸化水素の事前充填容器への拡散を減少させるまたは防止するための手段の適用を含めて、事前充填容器を制御可能蒸気化過酸化水素に曝露することによる最終滅菌をさらに含む。
