An endoscope cleaning sheath includes a flexible tube body that is mounted to an insertion portion having a bending portion included in an endoscope, and that has a plurality of through-holes parallel to a longitudinal axis and a cylindrical distal end nozzle that is provided at a distal end portion of the flexible tube body and that sprays at least one of a gas and a liquid at least at an observation window provided at a distal end portion of the insertion portion of the endoscope. The through-holes are a hole for an endoscope insertion portion through which the insertion portion of the endoscope is inserted, and at least a first fluid conduit that supplies gas and a second fluid conduit that supplies liquid. The first fluid conduit and the second fluid conduit are provided at positions in a direction that is different from a bending direction of the bending portion of the insertion portion that is inserted and disposed in the hole for an endoscope insertion portion.