KURAMOCHI, TAICHI,TANBA, SHIGERO,IGAWA, TOMOYUKI,MAEDA, ATSUHIKO,SAKATA, KIYOAKI,ENDOH, MIKA
申请号：
EP10818830
公开号：
EP2481752A4
申请日:
2010.09.24
申请国别(地区):
EP
年份:
2013
代理人:
摘要：
The present inventors successfully provided constant regions capable of enhancing the agonist activity of antibodies through amino acid sequence alterations. Specifically, agonist activity was found to be enhanced in antibodies having a constant region in which amino acids of the antibody heavy chain constant region are substituted or deleted, or antibodies having a constant region in which the hinge region amino acids are substituted. Use of such antibodies as pharmaceutical formulations can provide pharmaceutical formulations with improved performance.
