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NOUVEL ANTICORPS ANTIHUMAINS CIBLANT LA BETA-IG
专利权人:
ASTELLAS PHARMA INC.
发明人:
YAMAJUKU, DAISUKE,SEKI, MUTSUMI,HONDA, TAKASHI,KUBO, SATOSHI,SOGA, SHINJI,MORINAKA, AKIFUMI
申请号:
CA2957313
公开号:
CA2957313A1
申请日:
2015.08.05
申请国别(地区):
CA
年份:
2016
代理人:
摘要:
[Problem] To provide an anti-human Igß antibody in which BCR and Fc?RIIb are crosslinked and which has a more enhanced immunosuppressive function compared to conventional antibodies. [Solution] An anti-human Igß antibody including: a heavy-chain variable region that includes a CDR 1 comprising an amino acid sequence from amino acid numbers 31-35 of SEQ ID NO: 2, a CDR 2 comprising an amino acid sequence from amino acid numbers 50-65 of SEQ ID NO: 2, and a CDR 3 comprising an amino acid sequence from amino acid numbers 98-108 of SEQ ID NO: 2; a light-chain variable region that includes a CDR 1 comprising an amino acid sequence from amino acid numbers 24-38 of SEQ ID NO: 4, a CDR 2 comprising an amino acid sequence from amino acid numbers 54-60 of SEQ ID NO: 4, and a CDR 3 comprising an animo acid sequence from amino acid numbers 93-101 of SEQ ID NO: 4; and a heavy-chain constant region, said region being a human Ig?1 constant region having S239D, H268D, and L328W amino acid variations.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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