An extended release formulation of a direct thrombin inhibitor

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专利权人:

发明人:

RAMAKRISHNAN SANKAR,VENKATESAN ELUMALAI,SURYAKUMAR JAYANTHI,ALLARD STEPHANE

申请号：

IN4629/DELNP/2014

公开号：

IN2014DN04629A

申请日:

2014.06.07

申请国别(地区):

IN

年份:

2015

代理人:

摘要：

Extended release formu Mean DPOC-4088 plasma concentrations following single oral doses lations of 3-fluoro-2-pyridylmethyl-3- of an immediate release ( I ) formulation in healthy young men (2,2-difluoro -2-(2- pyridyl)ethylamino) - 6-chloropyrazin-2-one-l-acetamide (DPOC-4088) that provide for better control of blood plasma levels. The ex tended release formulations maintain substantially constant plasma levels of -t the active ingredient for at least about 16 hours and provide for once-daily dosing.

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