BOGHMANS CATHERINE PATRICIA L,MEEUS LIESBETH MARIA FERNANDE
申请号：
IN10877/CHENP/2012
公开号：
IN2012CN10877A
申请日:
2012.12.28
申请国别(地区):
IN
年份:
2015
代理人:
摘要：
Erythritol is granulated together with at least 10% w/w isomalt. Prior and/or after granulation a disintegrant is added and orodispersible tablets are prepared. The tablet has a disintegration time of less than 100 seconds less than 90 seconds preferably less than 80 seconds more preferably less than 60 seconds and said disintegration time was determined according to the European Pharmacopoeia VI Test method 2.9.1 by using a pharmaceutical disintegration tester model ZT 73 whereby 6 tablets having a surface of 1 square centimeter and a weight of 350 mg at a compression force of 20 kN were analyzed and mean values were calculated. The process for preparing the orodispersible tablet its use and the intermediate granulate are described as well.
