Sine Reker Hadrup,Vibeke Mindahl Rafa,Søren Nyboe Jakobsen
申请号：
US16470503
公开号：
US20190316069A1
申请日:
2017.12.20
申请国别(地区):
US
年份:
2019
代理人:
摘要：
The present invention relates to artificial antigen presenting cell (aAPC) scaffolds to provide cells with specific functional stimulation to obtain phenotypic and functional properties ideal to mediate tumor regression or viral clearance. In particular, the scaffolds of the present invention comprise antigens, such as peptide-MHC (pMHC) class I molecules, and specific combinations of cytokines and co-stimulatory molecules to allow effective expansion and functional stimulation of specific T cells.
