A tissue retrieval system includes a tissue retrieval bag with an elongate profile. The tissue retrieval bag can have a relatively large volume, but be rollable to a stowed configuration to fit in a relatively small diameter introducer. The tissue retrieval system includes one or more support arms coupled to the tissue retrieval bag, the support arms biased to position the tissue retrieval bag in an access position once deployed from the introducer. The tissue retrieval system can have a hybrid tissue retrieval bag including material properties that vary along the depth of the bag from an open end to a closed end. The tissue retrieval bag can be used in conjunction with an introducer, or as a stand alone tissue retrieval bag. The tissue retrieval bag is formed from a sheet of material having cuff portions folded and joined to the sheet to define a non-continous cuff, wherein the support arms are receivable in the non-continuous cuff. The tissue retrieval system includes a cord loop extending through the non-continuous cuff.
