A system for morcellating tissue within a body cavity is provided. The system includes a bag guide having a tubular body with proximal and distal ends, the distal end including a flange, a morcellator including an enlarged mouth for receipt within the flange of the bag guide, and a specimen bag receivable between the flange of the bag guide and the enlarged mouth of the morcellator. Also provided is a method of morcellating tissue within a body cavity.