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具抗細胞凋亡及/或保護肝臟之胜肽之用途及含有該胜肽之營養補充品
专利权人:
TUNGHAI UNIVERSITY
发明人:
江文德,林万登,JIANG, WEN-DE,LIN, WAN-DENG
申请号:
TW103118129
公开号:
TW201544117A
申请日:
2014.05.23
申请国别(地区):
TW
年份:
2015
代理人:
摘要:
The present invention discloses an isolated peptide, which is provided with an amino acid sequence encoded as SEQ ID No.1. The isolated peptide is capable of providing the effects in suppressing hepatocyte apoptosis, reducing a great amount of hepatic triglyceride accumulation, suppressing the expression of inflammatory cytokines, inhibiting expression of pro-apoptotic proteins, enhancing expression of survival factor, and inhibiting the expression of biomarker of hepatic fibrosis. Therefore, the peptide of the present invention can be used as the active ingredient in a medical composition for treating or preventing liver related diseases, or suppressing hepatocyte apoptosis. The liver related diseases are selected from the group consisting of hepatic fibrosis, fatty liver, hepatic inflammation, hepatic injury and apoptosis of hepatocytes.本發明係揭露一種單離之胜肽,其胺基酸序列係編碼為SEQ ID No.1。該單離之胜肽係具有抑制肝臟細胞凋亡、減少大量三酸甘油酯累積於肝臟、抑制發炎性細胞激素表現、抑制促細胞凋亡相關蛋白表現、促進細胞存活相關蛋白表現以及抑制肝纖維化細胞標記之表現等功效,因而能作為醫藥組合物之活性成份,用以預防或治療肝臟疾病,或是抑制肝細胞凋亡。
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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