The invention discloses a single isolated peptide, the amino acid sequence of which is encoded as SEQ ID No.1.The isolated peptide can inhibit the expression of signaling proteins related to cardiac hypertrophy pathway, cardiac apoptosis related proteins and cardiac fibrosis related proteins, and has the effect of avoiding inducing apoptosis, cardiac fibrosis, cardiac hypertrophy, cardiac inflammation or other cardiac diseases.According to this, Jiesheng peptide of the invention can be used as the active ingredient of the pharmaceutical composition to prevent or treat cardiovascular diseases.本發明所揭一種單離之胜肽，其胺基酸序列係編碼為SEQ ID No.1。該單離之胜肽係能夠抑制與心臟肥大路徑相關之訊息傳遞蛋白表現、抑制與心肌細胞凋亡相關蛋白之表現、抑制心臟纖維化相關蛋白之表現，而具有避免引發如心肌細胞凋亡、心臟纖維化、心臟肥大、心臟發炎或其他心臟病變之功效。據此，本發明所揭胜肽係能作為醫藥組合物之活性成份，達到預防或治療心血管疾病之功效。
