The present invention relates to a synergistic pharmaceutical formulation for enhancing gastric emptying and sphincter relaxation comprising of two components wherein the first component is in the form of a floating formulation and second component is in the form of a mucoadhesive formulation. The synergistic effect of these components has shown to enhance the gastric emptying time and this in turn results in instantaneous and fast forward propulsion of gastric contents (also called gastric prokinetic action) thereby helping in digestion.