MCCARRON, ASHLEY SUE,SELLS, TODD B.,STIRLING, MATTHEW,STROUD, STEPHEN G.
申请号：
CA2846231
公开号：
CA2846231C
申请日:
2012.08.23
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
Disclosed are chemical entities which are inhibitors of Nedd8-activatingenzyme (NAE), namely,the compound {(1S,2S,4R)-4-[(6-{[(1R,2S)-5-chloro-2-methoxy-2,3-dihydro-1H-inden-1-yl]amino}pyrimidin-4-yl)oxy]-2-hydroxycyciopentyl}methyl sulfamate having thestructure,(see structure)and pharmaceutically acceptable salts and solvates thereof； solid state formsthereof； andprodrugs thereof. Also disclosed are methods of using the chemical entities totreat disorderssuch as cancer.
