Общество с ограниченной ответственностью "НИАРМЕДИК ПЛЮС" (RU)
发明人:
Нестеренко Владимир Георгиевич (RU),Суслов Анатолий Петрович (RU),Дятлов Валерий Александрович (RU),Круппа Инна Сергеевна (RU)
申请号：
RU2014124783/04
公开号：
RU2014124783A
申请日:
2014.06.17
申请国别(地区):
RU
年份:
2015
代理人:
摘要：
1. Polymeric gossypol derivative having the following general formula (I): wherein R` = Sach R`` = Sach or H Sach - oxidized link pentoses or hexoses consisting of a polysaccharide, one of said formulas below: wherein R = -CHOH -CH (OH) CHOH -CHOR` -CH (OH) CHOR`.R` = -CHCHOH -CHCHNH -CHC (O) OH -SOH, -OSOH -CHC (O) OR``R`` = Alki molecular weight of from 1 to 2000 kDa.2. A compound according to Claim. 1, wherein the molecular weight is from 3 to 80 kDa.3. A process for preparing a polymer derivative gossypol general formula (I) according to Claim. 1 or 2, comprising oxidizing polysaccharide iodic acid or its salts to form an oxidized polysaccharide containing closed acetal or azomethine bond oxygenated cycles, subsequent isolation of the resulting oxidized polysaccharide and its interaction with gossypol or derivative thereof at a pH from 3.5 to 14 and the molar ratio of gossypol: oxidized polysaccharide link from 10: 1 to 1: 100.4. A method according to claim. 3, wherein the polysaccharide is a carboxymethylcellulase, hydroxyethyl cellulose, hemicellulose, dextran and derivatives thereof, alginic acid, inulin, starch and its derivatives such as oksietilkrahmal, carboxymethyl aminoetilkrahmal, karragennan, chitosan, and Ficoll proizvodnye.5 . A method according to claim. 3 or 4, wherein the polysaccharide has a molecular weight of from 1 to 2000 kDa, preferably from 3 to 80 kDa.6. A method according to claim. 3 or 4, wherein the polysaccharide oxidation is carried out with periodic acid or its salt, preferably sodium or potassium metaperiodate in aqueous or water-organic srede.7. A method according to claim. 3 or 4, wherein the polysaccharide oxidation is carried out using an anion exchange resin in forme.8 JO. A method according to claim. 3 or 4, wherein the interaction of gossypol with oxidized polysaccharide is carried out in solution or in1. Полимерное производное госсипола, имеющее следующую общую формулу (I):где R`=Sach R``=Sach или HSach - окисленное звено п
