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Poly-aromatic sodium channel blockers
专利权人:
PARION SCIENCES; INC.
发明人:
JOHNSON, MICHAEL R.
申请号:
ES09747034
公开号:
ES2485642T3
申请日:
2009.02.26
申请国别(地区):
ES
年份:
2014
代理人:
摘要:
A compound of formula (II) ** Formula ** in which A1 is represented by the formula: ** Formula ** and in which each Q is independently CH, C-R5, or C-R6, with the condition that at least one Q is C-R5; each R5 is, independently, OH, - (CH2) n-NR10-CH2 (CHOR8) (CHOR8) n-CH2OR8, -O- (CH2) m-NR10- CH2 (CHOR8) (CHOR8) nCH2OR8, Link- (CH2 ) n-CAP, Link- (CH2) n- (Z) g-CAP, or Link- (CH2) n (Z) g- (CH2) m-CAP; each R6 is independently R5, -R7, -OR11, -N (R7) 2, - (CH2) m-OR8, -O- (CH2) m-OR8, - (CH2) n-NR7R10, -O- (CH2) m- NR7R10, - (CH2) n (CHOR8) (CHOR8) n-CH2OR8, -O- (CH2) m (CHOR8) (CHOR8) n-CH2OR8, - (CH2CH2O) m-R8, -O- (CH2CH2O) m-R8, - (CH2CH2O) m-CH2CH2NR7R10, -O- (CH2CH2O) m-CH2CH2NR7R10, - (CH2) nC (>; = O) nR7R10, -O- (CH2) m- C (>; = O ) nR7R10, - (CH2) n- (Z) g-R7, -O- (CH2) m- (Z) g-R7, - (CH2) n-NR10-CH2 (CHOR8) (CHOR8) n-CH2OR8, -O- (CH2) m-NR10- CH2 (CHOR8) (CHOR8) n-CH2OR8, - (CH2) n-CO2R7, -O- (CH2) m-CO2R7, -OSO3H, -O-glucuronide, -O- glucose,Un compuesto de fórmula (II)**Fórmula** en la que A1 está representada por la fórmula:**Fórmula** y en la que cada Q es, independientemente, C-H, C-R5, o C-R6, con la condición de que al menos un Q sea C-R5; cada R5 es, independientemente, OH, -(CH2)n-NR10-CH2(CHOR8)(CHOR8)n-CH2OR8, -O-(CH2)m-NR10- CH2(CHOR8)(CHOR8)nCH2OR8, Link-(CH2)n-CAP, Link-(CH2)n-(Z)g-CAP, o Link-(CH2)n(Z)g-(CH2)m-CAP; cada R6 es, independientemente, R5, -R7, -OR11, -N(R7)2, -(CH2)m-OR8, -O-(CH2)m-OR8, -(CH2)n-NR7R10, -O-(CH2)m- NR7R10, -(CH2)n(CHOR8)(CHOR8)n-CH2OR8, -O-(CH2)m(CHOR8)(CHOR8)n-CH2OR8, -(CH2CH2O)m-R8, -O- (CH2CH2O)m-R8, -(CH2CH2O)m-CH2CH2NR7R10, -O-(CH2CH2O)m-CH2CH2NR7R10, -(CH2)n-C(>;=O)nR7R10, -O-(CH2)m- C(>;=O)nR7R10, -(CH2)n-(Z)g-R7, -O-(CH2)m-(Z)g-R7, -(CH2)n-NR10-CH2(CHOR8)(CHOR8)n-CH2OR8, -O-(CH2)m-NR10- CH2(CHOR8)(CHOR8)n-CH2OR8, -(CH2)n-CO2R7, -O-(CH2)m-CO2R7, -OSO3H, -O-glucurónido, -O-glucosa,
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