Anti-ADDL monoclonal antibody and use thereof

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专利权人:

メルク・シャープ・アンド・ドーム・コーポレーション

发明人:

キニー，ジーン,ストロール，ウイリアム，アール．,アン，ツィキャン,キニー,ジーン,ストロール,ウイリアム,アール.,アン,ツィキャン

申请号：

JP2008536730

公开号：

JP5289963B2

申请日:

2006.10.17

申请国别(地区):

JP

年份:

2013

代理人:

摘要：

The present invention relates to antibodies that -differentially -recognize- -multi- dimensional conformations- of- Aß- derived diffusible ligands, also known as ADDLs. The antibodies of the invention can distinguish between Alzheimer's Disease and control human brain extracts and are useful in methods of detecting ADDLs and diagnosing Alzheimer's Disease. The present antibodies also block binding of ADDLs to neurons, assembly of ADDLS, and tau phosphorylation and are there useful in methods for the preventing and treating diseases associated with soluble oligomers of amyloid ß 1-42.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/