A urine collection system includes a collection bag defining a fluid reservoir including a fluid inlet and a fluid outlet, an in-line vent positioned upstream of the collection bag and being fluidly coupled to the collection bag, the in-line vent including an outlet end, a sampling port adapter positioned upstream of the in-line vent and being adapted to be fluidly coupled to a urinary catheter and a compressible tube defining a fluid channel fluidly connecting the sampling port adapter and the in-line vent, the compressible tube being clampable to seal the fluid channel.
