A urine collection system (10) includes a collection bag (12) defining a fluid reservoir including a fluid inlet and a fluid outlet, an in-line vent (18) positioned upstream of the collection bag and being fluidly coupled to the collection bag, the in-line vent including an outlet end, a sampling port adapter (16) positioned upstream of the in-line vent and being adapted to be fluidly coupled to a urinary catheter (30) and a compressible tube (20) defining a fluid channel fluidly connecting the sampling port adapter and the in- line vent, the compressible tube being clampable to seal the fluid channel.
