PETER D. SENTER,MARK X. SLIWKOWSKI,SVETLANA O. DORONINA,BRIAN E. TOKI,ALLEN J. EBENS,TONI BETH KLINE,PAUL POLAKIS,SUSAN D. SPENCER
申请号：
PT04821486
公开号：
PT1725249E
申请日:
2004.11.05
申请国别(地区):
PT
年份:
2014
代理人:
摘要：
Auristatin peptides, including MeVal-Val-Dil-Dap-Norephedrine (MMAE) and MeVal-Val-Dil-Dap-Phe (MMAF), were prepared and attached to Ligands through various linkers, including maleimidocaproyl-val-cit-PAB. The resulting ligand drug conjugates were active in vitro and in vivo.
