L-PROLINE AND CITRIC ACID CO-CRYSTALS OF (2S,3R,4R,5S,6R)-2-(3-((5-(4-FLUOROPHENYL)THIOPHEN-2-YL)METHYL)- 4-METHYLPHENYL)-6-(HYDROXYMETHYL)TETRAHYDRO-2H-PYRAN-3,4,5-TRIOL
The present invention is directed to L-proline and citric acid co-crystals of (2S, 3R, 4R, 5S, 6R)-2-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)-6-(hydroxymethyl)tetra hydro-2H-pyran-3, 4, 5-triol, pharmaceutical compositions containing said co-crystals and their use in the treatment glucose-related disorders such as Type 2 diabetes mellitus and Syndrome X.本發明係有關於(2S,3R,4R,5S,6R)-2-(3-((5-(4-氟苯基)噻吩-2-基)甲基)-4-甲基苯基)-6-(羥甲基)四氫-2H-吡喃-3,4,5-三醇的L-脯胺酸與檸檬酸共晶體、含有該共晶體的醫藥組成物,以及其在如第二型糖尿病和X症候群等血糖相關疾病治療上的應用。
