The present invention provides a preparation method of delay release multi-drugs component oral disintegrate tablets for cough which has superior pharynx, larynx and tracheal mucosa flux properties, which may be used for the treatment of cough, cough type asthma, cold and cough, allergic cough, coughing and phlegm, bronchitis coughing caused by wind heat invasion on lungs, and earth worm cough. Therefore, preparation method of delay release multi-drugs component unit dosage formulation which comprises preferably Chlorpheniramine Maleate, Dextromethorphan Hydrobromide and levocetirizine dihydrochloride oral disintegrate tablets for cough, by wet granulation method in the invention is able to continuously and stably release drug in during a long time, as well as maintain effective and safe drug concentration.
