DENNIE JOHAN MARIJN VAN DEN HEUVEL,JOHANNES WILHELMUS MAURICE WEIJERS,DIRK PAMPERIN
申请号：
BRPI0823313
公开号：
BRPI0823313A2
申请日:
2008.12.09
申请国别(地区):
BR
年份:
2015
代理人:
摘要：
The invention relates to a population of tamsulosin-comprising pellets for oral administration of a combination dosage form containing physically separated a tamsulosin dose in the form of the population of the tamsulosin comprising pellets and at least one other dose of a pharmaceutically active substance, said pellets comprising tamsulosin hydrochloride uniformly dispersed in a carrier matrix, wherein (i) said pellets in the population have a size of less than about 1.4 mm and, advantageously, at least 90% of the pellets have a size of larger than 0.30 mm； and (ii) an average content of tamsulosin hydrochloride in the population of pellets is between about 0.15-3.00 weight percent, calculated on a dry pellet basis, to a process of making such population of pellets, and to their use.
