NOVEL CYP17 INHIBITORS/ANTIANDROGENS

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专利权人:

ORION CORPORATION

发明人:

WOHLFAHRT, Gerd,RUMMAKKO, Petteri,KARJALAINEN, Arja,PASSINIEMI, Mikko,PIETIKŽINEN, Pekka,HAIKARAINEN, Anssi,VŽISŽNEN, Emilia,TIAINEN, Eija

申请号：

PH12015502723

公开号：

PH12015502723B1

申请日:

2015.12.07

申请国别(地区):

PH

年份:

2016

代理人:

摘要：

Compounds of formula (I), wherein R1 to R8 A, B, Z1 and Z2 are as defined in the claims and pharmaceutically acceptable salts and esters thereof are disclosed. The compounds of formula (I) possess utility as androgen receptor antagonists (inhibitors) and/or cytochrome P450 monooxygenase 17a-hydroxylase/17,20-lyase (CYP17) inhibitors. The compounds are useful as medicaments in the treatment of cancer, particularly prostate cancer, and other androgen dependent conditions and diseases where androgen antagonism is desired.

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中国工程科技知识中心

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http://www.ckcest.cn/home/