Disclosed herein is acid addition salt cation steroidal antibacterial agent (referred to as " CSAs " or " ceragenins ") and manufacture its methods. Particularly advantageous salt form is identified, such as 1,5-naphthalenedisulfonic acid addition salts and sulfate addition salts. The acid addition salt can prepare treatment with disease in response to CSAs, including but not limited to treatment bacterium infection. Embodiment includes that the CSAs in preparation and method gives acid addition salt.