Compounds derived from Pyridine and pyrimidine substituted, - 3 - mediators of kynurenine monooxygenase； Pharmaceutical compositions containing same and use in the treatment of neurodegenerative disorders, such as Huntington's disease.
BROWN, CHRISTOPHER JOHN,COURNEY, STEPHEN MARTIN,JOHNSON, PETER,DOMINGUEZ, CELIA,TOLEDO-SHERMAN, LETICIA M.,MUÑOZ, IGNACIO,PRIME, MICHAEL,MITCHELL, WILLIAM,DE AGUIAR PENA, PAULA C.
申请号：
CL2014000447
公开号：
CL2014000447A1
申请日:
2014.02.25
申请国别(地区):
CL
年份:
2014
代理人:
摘要：
Certain chemical entities are provided herein. Also provided are pharmaceutical compositions comprising at least one chemical entity and one or more pharmaceutically acceptable vehicle. Methods of treating patients suffering from certain diseases and disorders responsive to the inhibition of KMO activity are described, which comprise administering to such patients an amount of at least one chemical entity effective to reduce signs or symptoms of the disease or disorder are disclosed. These diseases include neurodegenerative disorders such as Huntington's disease. Also described are methods of treatment include administering at least one chemical entity as a single active agent or administering at least one chemical entity in combination with one or more other therapeutic agents. Also provided are methods for screening compounds capable of inhibiting KMO activity.<；p>；Compuestos derivados de pirimidina con actividad inhibidora de quinurenina-3-monooxigenasa； composició；n farmacé；utica； ú；tiles en el tratamiento de una enfermedad neurodegenerativa, enfermedad de Huntington, entre otros.<；/p>；
