A pharmaceutical composition for transdermal delivery comprising one or more physiologically active agents； one or more dermal penetration enhancers； and a volatile pharmaceutically acceptable carrier comprising a volatile solvent； and wherein the physiologically active agent and dermal penetration enhancer form an amorphous deposit upon evaporation of the volatile carrier, said amorphous deposit forming a reservoir within the stratum corneum； and (A) wherein the composition has a release rate profile of physiologically active agent so as to provide a ratio of the maximum concentration (Cmax) to the average concentration (Cavg) for the physiologically active agent over the dosage interval within the range of 1 to 10.
