Timothy Matthias Morgan,Nina Frances Wilkins,Kathryn Traci-Jane Klose,Barrie Charles Finnin,Barry Leonard Reed
申请号：
US14305529
公开号：
US20150094290A1
申请日:
2014.06.16
申请国别(地区):
US
年份:
2015
代理人:
摘要：
A pharmaceutical composition for transdermal delivery comprisingone or more physiologically active agents；one or more dermal penetration enhancers； anda volatile pharmaceutically acceptable carrier comprising a volatile solvent；and wherein the physiologically active agent and dermal penetration enhancer form an amorphous deposit upon evaporation of the volatile carrier, said amorphous deposit forming a reservoir within the stratum corneum； and(A) wherein the composition has a release rate profile of physiologically active agent so as to provide a ratio of the maximum concentration (Cmax) to the average concentration (Cavg) for the physiologically active agent over the dosage interval within the range of 1 to 10.
