UNIVERSITY OF UTAH RESEARCH FOUNDATION;YOST, H., JOSEPH;PARANT, JOHN, M.
发明人:
YOST, H., JOSEPH,PARANT, JOHN, M.
申请号：
WO2010US61098
公开号：
WO2011075674(A2)
申请日:
2010.12.17
申请国别(地区):
世界知识产权组织国际局
年份:
2011
代理人:
摘要：
Disclosed are mutant non-human animals and methods of making the same. Also disclosed are methods and compositions of identifying mutant non-human animals comprising a mutation in the DNA binding domain of p53 or a mutation in a tumorigenic gene. Also disclosed are methods of identifying modulators of p53 activity, expression of a p53 pathway gene, tumorigenic gene expression, cancerous tissue growth, or tumorigenic gene activity. Also disclosed are compositions comprising a mutation in the DNA binding domain of p53.
