METHODS OF MODULATING CELL REGULATION BY INHIBITING P53

• 收藏
• 分享

专利权人:

LIXTE BIOTECHNOLOGY, INC.;KOVACH, JOHN, S.

发明人:

KOVACH, JOHN, S.

申请号：

WO2010US00279

公开号：

WO2010147612(A1)

申请日:

2010.02.01

申请国别(地区):

世界知识产权组织国际局

年份:

2010

代理人:

摘要：

Disclosed herein are methods of inhibiting the function of p53 in a cell by contacting the cell with an effective amount of a PP2A inhibitor. Also disclosed herein are processes for producing an induced pluripotent stem (iPS) cell by contacting a somatic cell expressing at least one gene that encodes a reprogramming factor with an amount of a PP2A inhibitor effective to produce the iPS cell; reversibly inhibiting p53 function during production of an iPS cell by contacting a somatic cell with an amount of a PP2A inhibitor effective to reversibly inhibit p53 function; increasing the likelihood of producing an (iPS) cell.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/