Cell-penetrating bacterial E3-ubiqitin-ligases for use in immunotherapy

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专利权人:

Westfälische Wilhelms-Universität Münster

发明人:

Marie-Luise Lubos,Alexander Schmidt,Christian Rueter

申请号：

US15022827

公开号：

US10406215B2

申请日:

2014.09.22

申请国别(地区):

US

年份:

2019

代理人:

摘要：

The present invention relates to cell-penetrating effector proteins of type III secretion system (T3SS)-containing bacteria of the genus Salmonella or Shigella and variants, fragments and immunomodulatory domains thereof, for use in immunotherapy. The present invention further relates to cell-penetrating effector proteins of type III secretion system (T3SS)-containing bacteria of the genus Salmonella or Shigella and variants, fragments and immunomodulatory domains thereof, for delivering cargo molecules into eukaryotic cells.

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