Barbier, Ann,McCauley, Thomas,Richard , Charles W.
申请号:
AU2012358223
公开号:
AU2012358223A1
申请日:
2012.12.21
申请国别(地区):
AU
年份:
2014
代理人:
摘要:
The present invention, provides a method of treating cognitive impairment of Hunter syndrome. Among other things, the present invention provides a method comprising a step of administering intrathecally to a subject in need of treatment a recombinant iduronate-2-sulfatase (I2S) enzyme at a therapeutically effective dose and an administration interval for a treatment period sufficient to improve, stabilize or reduce declining of one or more cognitive, adaptive, motor, and/or executive functions relative to a control