Ann BARBIER,Thomas MCCAULEY,Charles W. RICHARD, III
申请号：
US14367864
公开号：
US20150328289A1
申请日:
2012.12.21
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present invention, provides a method of treating cognitive impairment of Hunter syndrome. Among other things, the present invention provides a method comprising a step of administering intrathecally to a subject in need of treatment a recombinant iduronate-2-sulfatase (I2S) enzyme at a therapeutically effective dose and an administration interval for a treatment period sufficient to improve, stabilize or reduce declining of one or more cognitive, adaptive, motor, and/or executive functions relative to a control
