The present invention is related to carboxylic acids of Formula (I) and usethereof for the treatment and/or prevention of obesity and/or metabolicdisorders mediated by insulin resistance or hyperglycemia, comprising diabetestype I and/or II, inadequate glucose tolerance, insulin resistance,hyperlipidemia, hypertriglyceridemia, hypercholesterolemia, polycystic ovarysyndrome (PCOS). In particular, the present invention is related to the use ofcarboxylic acids of Formula (I) to modulate, notably to inhibit the activityof PTPs.