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SPIRO(5,5)UNDECANE DERIVATIVES
专利权人:
GRJUNENTAL' GMBKH;GRJUNENTAL GMBKH
发明人:
Zaskia TsEMOL'KA (DE),Заскиа ЦЕМОЛЬКА (DE),Shtefan ShUNK (DE),Штефан ШУНК (DE),Klaus LINTs (DE),Клаус ЛИНЦ (DE),Vol'fgang ShReBER (DE),Вольфганг ШРёБЕР (DE),Verner EhNGL'BERGER (DE),Вернер ЭНГЛЬБЕРГЕР,ZASKIA TSEMOLKA,Заскиа ЦЕМОЛЬКА,SHTEFAN SHUNK,Штефан ШУНК,KLAUS LINTS,Клаус ЛИНЦ,VOLFGANG SHREBER,Вольфганг ШРёБЕР,VERNER EHNGLBERGER,FRITTS TAJL,Фритц ТАЙЛЬ,BIRGIT ROLOFF,Биргит РО
申请号:
RU2010143446/04
公开号:
RU0002515895C2
申请日:
2009.03.25
申请国别(地区):
RU
年份:
2014
代理人:
摘要:
FIELD: chemistry.SUBSTANCE: invention relates to field of organic chemistry, namely to compound of general formula (1), where A1 represents -N= or -CR7=, A2 represents -N= or -CR8, A3 represents -N= or -CR9=, A4 represents -N= or -CR10=; on condition that not more than one of residues A1, A2, A3 and A4 represents -N=; Y1, Y1′, Y2, Y2′, Y3, Y3′, Y4 and Y4' in each case independently on each other represent -H or -C1-8-alkyl; W represents -NR4-, where R4 represents -H or -C1-8-alkyl; R1, R2 and R3 independently on each other in each case represent R0, where R0 represents non-substituted or monosubstituted -C1-8-alkyl; non-substituted or monosubstituted -phenyl; non-substituted or monosubstituted - heteroaryl or non-substituted or monosubstituted -C1-8-alkylphenyl; or R1 and R2 together represent -(CH2)3-6-; R5, R5' R6, R6' R7 R8, R9, R10, R18 and R19 in each case independently on each other are selected from group, including -H, -F, -Cl, -Br, -I and -R0; where "heteroaryl" represents 5-membered cyclic aromatic residue, which contains 1 heteroatom, where heteroatom represents sulphur; where "alkyl" in each case represents branched or non-branched, saturated, non-substituted or monosubstituted aliphatic hydrocarbon residue; where with respect to residues "phenyl", "-C1-8-alkyl", "heteroaryl" and "-C1-8-alkylphenyl" "monosubstituted" means monosubstitution of one hydrogen atom with substituents, selected from group, including -F, -Cl, -Br, -I or -OH, in form of single stereoisomer or their mixture, free compound and/or its physiologically compatible salts.EFFECT: obtained is novel compound and medication based on thereof, which can be applied in medicine for pain treatment.9 cl, 15 exИзобретение к области органической химии, а именно к соединению общей формулы (1)где A1 представляет собой -N= или -CR7=, A2 представляет собой -N= или -CR8, А3 представляет собой -N= или -CR9=, A4 представляет собой -N= или -CR10=; при условии, что не более чем один из остатков A1, A2, А
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