Growth hormone releasing peptides

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专利权人:

S.A.S;Ipsen Pharma

发明人:

Zheng Xin Dong

申请号：

US13734314

公开号：

US08859729B2

申请日:

2013.01.04

申请国别(地区):

US

年份:

2014

代理人:

摘要：

Disclosed are peptide and peptidomimetic compounds generally according to formula (I) that are useful as GHRP analogs:R1-A1-A2-A3-A4-A5-R2  (I)wherein:A1 is Aib, Apc or Inp；A2 is D-Bal, D-Bip, D-Bpa, D-Dip, D-1Nal, D-2Nal, D-Ser(Bzl), or D-Trp；A3 is D-Bal, D-Bip, D-Bpa, D-Dip, D-1Nal, D-2Nal, D-Ser(Bzl), or D-Trp；A4 is 2Fua, Orn, 2Pal, 3Pal, 4Pal, Pff, Phe, Pim, Taz, 2Thi, 3Thi, Thr(Bzl)；A5 is Apc, Dab, Dap, Lys, Orn, or deleted；R1 is hydrogen, (C1-6)alkyl, (C5-14)aryl, (C1-6)alkyl(C5-14)aryl, (C3-8)cycloakyl, or (C2-10)acyl； andR2 is OH or NH2；and pharmaceutical compositions and methods of use thereof.

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